Multiple BA.4 and BA.5 subvariants with R346 mutations on the spike glycoprotein have been identified in various countries, such as BA.4.6/BF.7 harboring R346T, BA.4.7 harboring R346S, and BA.5.9 harboring R346I. These subvariants, especially BA.4.6, exhibit substantial growth advantages compared to
CD8+ T cells are responsible for the recognition and killing of cancer cells. Following persistent exposure to its cognate tumor antigen in cancer, a CD8+ T cell will undergo differentiation towards a dysfunctional status, which is marked by the up-regulation of co-inhibitory molecules and by the p
Multimodal neuroimaging plays an important role in neuroscience research.Integrated noninvasive neuroimaging modalities, such as magnetoencephalography(MEG),electroencephalography (EEG) and functional near-infrared spectroscopy(fNIRS),allow neural activity and related physiological processes in the
Whether adult hippocampal neurogenesis (AHN) persists in adult and aged humans continues to be extensively debated. A major question is whether the markers identified in rodents are reliable enough to reveal new neurons and the neurogenic trajectory in primates. Here, to provide a better understandin
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage1. The receptor binding and immune-evasion capability of these recently emerged variants require immediate investigation. Here, coupled with
Ribosome associated complex(RAC), an obligate heterodimer of HSP40 and HSP70(Zuo1and Ssz1 in veast is conserved in eukarvotes and functions as co-chaperone for another HSP70(Sso1/2 in yeast)to facilitate co-translational folding of nascent polypeptides.Many mechanistic details, such as the coordinat
With rapid advances in recent years, single-cell omics technologies have become essential tools for studying cellular function and gene regulation. Up until now, many omics layers can be profiled at single-cell resolution, including transcriptome, chromatin accessibility, chromatin contact, DNA methylation
SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8, 2022, in Tianjin and caused a large wave of infections.
COVID-19 vaccination campaigns are being conducted in countries worldwide, and 47.4% of the world population has received at least one dose of a COVID-19 vaccine.1 Although vaccination has shaped COVID-19 epidemic curves, waning antibody levels and relatively short-duration protection provided by cu
